Specify your search terms. For example, instead of searching for the broad subject of 'Substance Use Disorders,' search for a specific substance.
Reduce your search terms. Identify research that is about one of your key concepts rather than two of your key concepts combined. Then, use your own analysis to synthesize and integrate the information as clearly and true-to-scope as possible.
Follow rabbit holes. When you do find the perfect article, review their References/Works Cited List to discover overlapping or connecting research.
If the database where the article is housed has "Similar" or "Related" works listed, investigate those, as well.
Problem - Irrelevant results
Pivot
defined by Merriam-Webster as an "adjustment or modification made (as to a strategy) in order to adapt or improve"
Revisit your search terms
Are they spelled correctly?
Are they the correct terms?
Are you using jargon or non-jargon, and is that influencing your results?
Refine your subject knowledge.
Did you take time to fully understand your topic using credible reference sources? If not, you may be on the wrong track without realizing it.
Boukhris, T., Sheehy, O., Mottron, L., & Bérard, A. (2016). Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatrics, 170(2), 1-8. https://doi.org/10.1001/jamapediatrics.2015.3356
Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., & Magnusson, C. (2013). Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: Population based case-control study. BMJ (Online), 346(7907), 12-12. https://doi.org/10.1136/bmj.f2059
Harrington, R. A., Lee, L., Crum, R. M., Zimmerman, A. W., & Hertz-Picciotto, I. (2014). Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay. Pediatrics (Evanston), 133(5), e1241-e1248. https://doi.org/10.1542/peds.2013-3406